Effects of Aminoguanidine on Apoptosis in the Hippocampus and Memory Disorder in a Rat Model of Alzheimer’s Disease

Background: Memory loss is the main disorder accompanied by Alzheimer's disease (AD). Objectives: We aimed to investigate protective effects of aminoguanidine (Amg) on cell apoptosis in hippocampal CA1 region and memory impairment male rats received scopolamine (Scop). Methods: Thirty Wistar (200 - 250 g) were randomly divided into three groups saline-saline group, Scop + saline, Amg groups. The intraperitoneal injection (3 mg/kg) for seven days, subsequently, 100 mg/kg or normal saline intraperitoneally administrated 14 consecutive days. Morris water maze test was used study deficits. Finally, animals anesthetized, hippocampi quickly removed, histological performed, evaluated cresyl violet staining terminal deoxynucleotidyl transferase dUTP nick end labeling test, respectively. Results: resulted reduced pyramidal cells increased area, impaired spatial learning memory. administration significantly improved density area (P < 0.01). Also, number apoptotic hippocampus group decreased compared 0.05). Conclusions: These data demonstrate that declined Scop-induced rat model AD. It suggested may have against